FIGURE 1.
Model validation in control subjects. (a) A significant, positive relationship was identified between chronological age and predicated age in control subjects (R = 0.70, R 2 = 0.49, p > .0001). (b) A significant negative relationship was observed between chronological age and predicated age difference (predicted age − chronological age) in control subjects (R = −0.33, R 2 = 0.18, p > .0001). (c) While the effect was small, we continued to observe a significant relationship when plotting the residual effects of the linear relationship between predicted age difference and chronological age (shown in Figure 1b) with chronological age in controls (R = 0.04, R 2 = 0.002, p = .05)