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PKM2 can improve the depressive behavior of PSD rats. (a) The body weight. (b) The sucrose preference rate in SPT. (c) The immobility time in FST. (d,e) The horizontal movement and vertical movement in OFT of sham, stroke, or PSD rats at indicated time points in response to intranasal administration of saline or PKM2. Data were presented as the mean ± SD with three independent experiments. *p < .05, **p < .01 versus sham group, and ## p < .01 versus PSD group
