FIGURE 5.

PKM2 promotes activation of the MAPK/ERK pathway by activating VEGF expression. (a) The protein levels of PKM2, ERK, and VEGF in PSD rat, as determined using western blotting. Relatively quantitative results were determined by Image J and shown as histogram. (b) IHC assay was applied to examine the protein levels of PKM2, ERK, and VEGF in PSD rat. Data were presented as the mean ± SD with three independent experiments. **p < .01 versus sham group, ^## p < .01 versus PSD group, and ^@@ p < .01 versus PSD + rPKM2 (224 ng/kg) group