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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Trends Pharmacol Sci. 2021 Jul 28;42(9):729–744. doi: 10.1016/j.tips.2021.06.005

Figure 1. Structure of the Nrf2 protein depicting its function and regulation.

Figure 1.

Green line or font indicates negative regulation of Nrf2 activity as a transcription factor. Red line or font indicates factors governing activation of the Nrf2 transcription factor. Orange boxes show the domains important for the activity of the Nrf2 transcription factor, whereas blue boxes indicate the domains containing negative regulators. The border colors reflect five exons encoded by the Nrf2 gene. Abbreviations: β-TrCP, β-transducin repeat-containing protein; CHD6, chromo-ATPase/helicase DNA binding protein; GSK3β, glycogen synthase kinase 3β; NES, nuclear export sequence; NLS, nuclear localization sequence; RXRα, retinoid X receptor alpha.