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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Trends Pharmacol Sci. 2021 Jul 28;42(9):729–744. doi: 10.1016/j.tips.2021.06.005

Figure 4. Predicted functions of Nrf2 in the myocardium based on its downstream genes.

Figure 4.

The downstream genes were revealed by microarray or RNA-seq as transcripts increased or reduced due to Nrf2 activation or deficiency or are targets of Nrf2 binding as determined by DNA sequencing following ChIP. Underlines indicate the genes, expression of which has been found in cardiomyocytes in culture or in mouse myocardium related to Nrf2 status. Color shade reflects the ratio of genes in the functional group under the control of Nrf2 in the myocardium and the amount of literature validating the function by Nrf2 inducers or Nrf2 knockout in experimental animals. Abbreviations: Cat, catalase; c/EBP, CCAAT-enhancer-binding protein; GPx, glutathione peroxidase; GSH-R, glutathione reductase; GST, glutathione S transferase; HbEGF, heparin-binding epidermal growth factor-like growth factor; HO-1, heme oxygenase 1; MT, metallothionein; NF-κB, nuclear factor kappa B; NQO1, NAD(P)H: quinone oxidoreductase 1; Pdx, peroxiredoxin; PGC1α, peroxisome proliferator-activated receptor gamma activator 1 alpha; PINK1, PTEN-induced kinase 1; SOD, superoxide dismutase; Srxn, sulfiredoxin; TGF, transforming growth factor; Trx, thioredoxin; TrxR, thioredoxin reductase; VEGF, vascular endothelial growth factor.