TABLE 1.
Primary HHV-7 infection in British children: antibody responses and detection of viral DNA
| Patient no. | Age (mo) | Day after onset of symptoms | Serum or plasma
|
|||||
|---|---|---|---|---|---|---|---|---|
| HHV-6 IgG titera
|
HHV-6 DNA | HHV-7 IgG titera
|
HHV-7 DNA | |||||
| Without urea | With urea | Without urea | With urea | |||||
| 10 | 17 | 4 | <8 | <8 | − | <8 | <8 | + |
| 11 | 16 | NTb | − | 512 | 8 | − | ||
| 41c | <16 | <16 | NT | 512 | 16 | NT | ||
| 168 | 8 | <8 | − | 512 | 128 | − | ||
| 11 | 21 | 10 | <8 | <8 | − | <8 | <8 | − |
| 172cd | <16 | <16 | NT | 2,048 | 64 | NT | ||
| 206 | <8 | <8 | − | 1,024 | 32 | − | ||
| 334 | <8 | <8 | − | 256 | 64 | − | ||
| 340c | <16 | <16 | NT | 512 | 256 | NT | ||
| 12 | 13 | 3 | 512 | 256 | − | 64 | 8 | + |
| 15c | 8,192 | 4,096 | NT | 8,192 | 16 | NT | ||
| 96 | 1,024 | 2,048 | − | 4,096 | 32 | − | ||
| 119e | 512 | NT | NT | 256 | 64 | NT | ||
a
Those sera whose antibody titers were reduced eightfold or greater by urea are defined as having low-avidity antibody and the results are highlighted in bold. Those sera whose titers were reduced fourfold or less by urea are defined as having high-avidity antibody.
b
NT, not tested.
c
Saliva contained HHV-7 DNA but not HHV-6 DNA.
d
Patient 11 presented with an encephalopathic Illness. HHV-7 seroconversion was picked up by chance in a convalescent-phase specimen.
e
Saliva contained HHV-7 DNA and HHV-6 DNA.