Table 3.

Severe Traumatic Brain Injury

Author	Aim of study	Country	Methodology	Period	Sample size	Outcome measures	Summary of findings
Thelin 2017	To evaluate the Stockholm and Helsinki CT scores for predicting functional outcome, in comparison with the Rotterdam CT score and Marshall CT classification. To assess which individual components of the CT scores best predict outcome and what additional prognostic value the CT scoring systems contribute to a clinical prognostic model	United Kingdom	Prospective cohort	2005–2014	1115	• CT severity score as predictor of GOS	• TSAH was the most important component of the Stockholm and Helsinki CT scoring system for outcome prediction
Matsushima 2015	To investigate the relationship between time to surgery and outcomes in patients with isolated sTBI requiring an emergent neurosurgical intervention	USA	Prospective cohort	2003 – 2013	161	• Inhospital mortality	• Inhospital mortality rate: 34.5% (early) vs. 59.1% (late) • Neurosurgical intervention was significantly associated with a higher odds of patient survival
Tu 2011	To evaluate whether the maximum thickness of subarachnoid blood is an independent prognostic marker of mortality after TSAH	China	Prospective cohort	2007–2010	104	• 1-month mortality	• Maximum thickness of subarachnoid blood is a prognostic marker of 1-month mortality

CT, computed tomography; GOS, Glasgow Outcome Score; sTBI, severe traumatic brain injuryt; TSAH: traumatic subarachnoid hemorrhage.