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PTUPB and RB394 represent different types of multi-target drugs. PTUPB is an example of a linked multi-target drug with a distinct pharmacophore for cyclooxygenase-2 (COX-2) inhibition and soluble epoxide hydrolase (sEH) inhibition (left). RB394 is an example of a merged multi-target drug that unites the pharmacophore features required for sEH inhibition and PPARγ activation (right). EC50, half maximal effective concentration; IC50, half maximal inhibitory concentration
