. 2021 Aug 2;2(10):1645–1653. doi: 10.34067/KID.0003582021

Table 2.

Multi-target drug targets, dosages, pharmacokinetics, and references

Multi-target Drug	Targets	Dosages and Administration Routes	Pharmacokinetics	References
PTUPB	sEH	5–10 mg/kg per d s.c.	Data in references (31,34)	(26,31,33–35,37–39)
	sEH	10–30 mg/kg per d p.o.
	COX-2	10–30 mg/kg per d p.o.
	COX-2	30–60 mg/kg per d i.p.
RB394	sEH	10 mg/kg per d p.o.	Data in reference (45)	(45–48)
RB394	PPARγ	10 mg/kg per d p.o.	Data in reference (45)	(45–48)
DM509	sEH	10 mg/kg per d p.o.	Data in reference (53)	(53–55)
DM509	FXR	10 mg/kg per d p.o.	Data in reference (53)	(53–55)
INT-767	FXR	10–30 mg/kg per d p.o.	Data in references (56,72)	(56–62,72)
INT-767	TGR5	10–30 mg/kg per d p.o.	Data in references (56,72)	(56–62,72)

sEH, soluble epoxide hydrolase; s.c., subcutaneous; COX-2, cyclooxygenase-2; p.o., by mouth; i.p., intraperitoneal; PPARγ, peroxisome proliferator-activated receptor γ; FXR, farnesoid X receptor; TGR5, Takeda G protein receptor 5.