Table 1.
Clinical manifestation of previous reported CADASIL with parkinsonism.
| References | Sex/age | Age of onset | Exome | Amino acid change | Symptoms | Other symptoms | Family history | Other phenotypes of other family members |
|---|---|---|---|---|---|---|---|---|
| Van Gerpen et al. (6) | F/60y | 54 | NA | NA | Symmetric PDS | Dementia/ stroke |
Y | Dementia, stroke |
| Wegner et al. (3) | M/55y | 53 | NA | NA | Asymmetric PDS/ upward gaze palsy | Dementia/ depression/ urinary incontinence |
N | NA |
| Valenti et al. (7) | M/64y | 60 | 24 | C1315T | Symmetric PDS | Dementia | Y | PDS/stroke/ Dementia |
| Ragno et al. (8) | 4M1F/63.0 ± 9.3y | 61 ± 8 | 19 | A1006C | 1 asymmetric PDS/ 4 symmetric PDS | Dementia | Y | Dementia, stroke |
| Erro et al. (1) | M/76y | 72 | 3 | R103X | Asymmetric PDS/ upgaze supranuclear palsy | Dementia | Y | Stroke |
| Ragno et al. (2) | M/75y | 75 | 19 | A1006C | Asymmetric PDS | MCI | N | NA |
| Our case | F/60y | 58 | 11 | R544C | Asymmetric PDS/RBD | Urinary incontinence | N | NA |
F, female; M, male; PDS, parkinsonian syndrome; RBD, rapid-eye-movement behavior disorder; MCI, mild cognitive impairment; Y, yes; N, no; NA, no information available.