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. 2022 Jan 10;12:826067. doi: 10.3389/fimmu.2021.826067

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Copyright © 2022 Han, Cen, Ou, Pan, Zhang, Huo and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential mechanism of interaction between berberine combined with methimidazole and thyroid clinical indexes. (A) Significantly different strains, metabolic pathways and thyroid function indicators are based on Spearman correlation coefficients together to form this correlation network. Edge width and color (positive correlation in red, negative correlation in blue) are proportional to the correlation strength of the co-occurrence probabilities. Node size is proportional to the average abundance of the respective populations. (B) Simplified visualization schematic with possible mechanisms of action including the gut-hypothalamus axis and the gut-thyroid axis.