Table 2.
Single-cell atlases
| Species (genotype) | Disease/Model | Method(s) | Website Link |
|---|---|---|---|
| Mouse (C57BL6/J) | Fibrosis (R-UUO) | scRNA-seq | Gene Atlas of Reversible Unilateral Uretic Obstruction Model: http://www.ruuo-kidney-gene-atlas.com |
| Mouse (C57BL6/J) | Healthy (aging, 1–30 months) | Bulk RNA-seq, scRNA-seq, | Tubula Muris Senis: https://tabula-muris-senis.ds.czbiohub.org |
| Mouse (C57BL6/J) | Acute injury (LPS-induced endotoxemia) | scRNA-seq | Mouse Kidney Single-cell Expression: https://connect.rstudio.iu.edu/content/18/ |
| Mouse (CFW) | Acute injury (IRI) | scRNA-seq | Mouse IRI scRNA: https://research.cchmc.org/PotterLab/scIRI/ |
| Mouse (C57BL6/J) | Healthy, fibrosis (FAN) | scRNA-seq, snATAC-seq | Susztaklab Kidney Biobank: https://susztaklab.com |
| Human | Healthy | ||
| Mouse (C57BL6/J) | Healthy, fibrosis (UUO), acute injury (IRI) | scRNA-seq, snRNA-seq | Kidney Interactive Transcriptomics (KIT): http://humphreyslab.com/SingleCell/ |
| Human | Allograft rejection, diabetes | ||
| Human | Healthy (including fetal) | scRNA-seq | Kidney Cell Atlas: https://www.kidneycellatlas.org |
| Human | Healthy (including fetal) | scRNA-seq | Nephrocell: http://nephrocell.miktmc.org |
| Human | Healthy (fetal) | scRNA-seq | The Human Nephrogenesis Atlas: https://sckidney.flatironinstitute.org |
Single-cell expression atlases from studies discussed in this review and of interest. R-UUO, reversible unilateral ureteral obstruction; scRNA-seq, single-cell RNA sequencing; IRI, ischemic reperfusion injury; FAN, folic acid nephropathy; snATAC-seq, single-nuclear assay for transposase-accessible chromatin using sequencing; snRNA-seq, single-nuclear RNA sequencing.