Table 1.
The markers and origin(s) of myeloid cells in kidney
| Myeloid Cell Type | Marker(s) | Origin | Reference |
|---|---|---|---|
| Neutrophil | CD45+, CD16+, CD66b+ (homo), CD45+, Ly-6G/ Gr-1+, CD11b+ (mus) | HSCs | (14) |
| Eosinophil | CCR3+, CD125+, CD49d+, Siglec-8+ (homo), Siglec-F (mus) | HSCs | (15) |
| Basophil | FcεRIα+, CD49b+, CD203c+, Thy1+, c-Kit-, FcγR+, Siglec-2+ (homo) | HSCs | (16) |
| Mast cell | CD11b−, Lin−, c-Kithigh, MITF+, CD33+ (homo), FcεRIα+, IL-3Rα+, CD203c+ | HSCs | (17) |
| Monocyte/macrophage | CD11b+, CSF1R+, Ly-6C+, Ly-6G−, F4/80+ (mus), EMR1+ (homo), CX3CR1+, CCR2+ | HSCs | (18) |
| Resident macrophage | CD45+, CD11blow, F4/80high, Ly-6C− (yolk sac EMP-derived resident macrophage) | Yolk sac EMPs, fetal liver EMPs, and HSCs | (19) |
| Dendritic cell | CD11c+, MHC-II+, CD103+, CD11blow, CX3CR1−, F4/80−, SIRP-α− (CD103+ renal DC), CD11b+, CD103−, CX3CR1+, F4/80+, SIRP-α+ (CD11b+ DC) | HSCs | (18,20) |
homo, Homo sapiens; mus, Mus musculus; HSCs, hematopoietic stem cells; EMP, erythro-myeloid progenitor; DC, dendritic cell.