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. Author manuscript; available in PMC: 2022 Jan 24.
Published in final edited form as: Biomaterials. 2008 Nov 4;30(4):611–621. doi: 10.1016/j.biomaterials.2008.09.061

Table 1.

Comparison of protective effects of three fullerene derivatives Gd@C82(OH)22, C60(OH)22, and C60(C(COOH)2)2 on H2O2-induced cytotoxcity and intracellular ROS generation in A549 cells or rBCECs cells.

Percentage of inhibition (%) Cell viability
Total ROS Level
A549 rBCECs A549 rBCECs
Gd@C82(OH)22 59.1±3.3 54.1±1.9 94.6±2.6 93. 5±3.4
C60(OH)22 37.1±3.5 35.5±3.3 74.1±3.5 72.7±2.9
C60(C(COOH)2)2 17.2±3.8 27.8±1.9 47.2±2.2 20.4±1.8

Note: For measuring effects on cell viability, the cells were treated with 100 μmol/ml fullerene derivatives before incubation with 50 μM H2O2. Cell viability was assessed by measurement of mitochondrial dehydrogenase activity. For measurement of intracellular ROS, the same conditions for incubation with H2O2 were used. Levels of intracellular ROS were determined by flow cytometry.