Figure 3.

Box plots (median [bold line], interquartile range [IQR] [box], ±1.5 × IQR [whiskers] and outliers [points]) showing the total Sequential Organ Failure Assessment (SOFA) score and its component parts combining all sampled time points. The neurologic component was not recorded due to difficulties in its measurement in sedated patients. The highest total SOFA score possible was therefore 20. Data are shown for all samples taken over approximately the first week of ICU stay matched to daily clinical information. Blue boxes combine all samples where the oxylipin concentration was below the level of quantification and yellow where they were above the level of quantification. A, 8,9-dihydroxyeicosatrienoic acid (DHET). B, 11,12-DHET. C, 14,15-DHET. Mixed-effects logistic models showed higher daily total SOFA scores were associated with detectable 14,15-DHET (odds ratio [OR], 1.27; 1.12–1.45; p < 0.001).