TABLE 1.

Comparison of Baseline Oxylipin Concentration Between 28-Day Septic Shock Survivors and Nonsurvivors

Oxylipin	28-Day Survivors (Median [IQR], fg/µL)	28-Day Nonsurvivors (Median [IQR], fg/µL)	p	Adjusted p
C20:3 (dihomo-γ-linolenic acid)	2.0 × 105 (1.5 × 105–2.8 × 105)	1.6 × 105 (1.2 × 105–2.4 × 105)	0.07	0.18
C20:5 (eicosapentaenoic acid)	3.3 × 105 (2.2 × 105–5.8 × 105)	2.7 × 105 (1.7 × 105–4.0 × 105)	0.01	0.08
9(S)-HODE	5,000 (5,000–5,000)	5,000 (5,000–5,000)	0.70	0.74
13(S)-HODE	10,126 (7,101–16,699)	11,749 (7,740–22,720)	0.29	0.36
12(S)-hydroxyeicosapentaenoic acid	703 (500–3,491)	2,243 (500–8,163)	0.10	0.18
5,6-EET	250 (250–250)	250 (250–250)	0.53	0.62
11,12-EET	250 (250–269)	250 (250–250)	0.24	0.32
5(S)-HETE	1,269 (963–1,908)	1,454 (888–1,852)	0.81	0.81
8(S)-HETE	292 (250–582)	424 (250–976)	0.11	0.18
11(R)-HETE	376 (253–662)	578 (269–1,094)	0.10	0.18
12(R)-HETE	4,028 (1,172–16,254)	7,741 (2,664–30,969)	0.07	0.18
15(S)-HETE	1,183 (817–1,904)	1,745 (1,070–3,485)	0.02	0.14
8,9-DHET	250 (250–250)	250 (250–267)	0.24	0.32
11,12-DHET	250 (250–250)	250 (250–317)	0.04	0.16
14,15-DHET	250 (250–292)	294 (250–474)	0.001	0.02
14-HDoHE	2,636 (1,128–7,856)	4,700 (1,750–21,351)	0.04	0.16
17(S)-HDoHE	500 (500–599)	500 (500–841)	0.10	0.18
LTB4	250 (250–250)	250 (250–250)	0.15	0.23
12-oxo-LTB4	500 (500–500)	500 (500–500)	0.10	0.18
Thromboxane B2	513 (250–3,074)	512 (250–5,019)	0.58	0.64

DHET = dihydroxyeicosatrienoic acid, EET = epoxyeicosatrienoic acid, HDoHE = hydroxydocosahexaenoic acid, HETE = hydroxyeicosatetraenoic acid, HODE = hydroxyoctadecadienoic acid, IQR = interquartile range, LTB4 = leukotriene B4.

Data given as median and IQR. Raw and adjusted p values are given, adjustment was performed using the Benjamini-Hochberg procedure. Adjusted p values in bold are those less than 0.05.