Table 3.
The sensitivity and specificity of STEC cluster/serotype-specific gene markers.
| Clusters | Cluster-specific genes marker sets | Identification dataset (3,258 isolates) | ||
|---|---|---|---|---|
| No. of isolates | Sensitivity | Specificity* | ||
| O157:H7 | Set of 6 genes | 356 | 100 | 99.72 |
| C1 | Set of 4 genes | 414 | 100 | 99.82 |
| C2 | Set of 4 genes | 181 | 100 | 99.97 |
| C3 | Set of 3 genes | 45 | 100 | 100 |
| C4 | Set of 3 genes | 89 | 100 | 99.97 |
| C5 | Set of 4 genes | 29 | 100 | 100 |
| C6 | Set of 3 genes | 41 | 100 | 99.88 |
| C7 | Set of 4 genes | 40 | 100 | 99.97 |
| C8 | Set of 5 genes | 40 | 100 | 99.97 |
| C9 | Set of 2 genes | 4 | 100 | 100 |
| C10 | Set of 2 genes | 50 | 100 | 100 |
| C11 | Single gene | 27 | 100 | 100 |
| C12 | Set of 2 genes | 21 | 100 | 100 |
| C13 | Set of 4 genes | 10 | 100 | 100 |
| C14 | Set of 4 genes | 16 | 100 | 99.97 |
| C15 | Set of 2 genes | 5 | 100 | 100 |
| C16 | Set of 4 genes | 14 | 100 | 99.97 |
| C17 | Set of 3 genes | 24 | 100 | 99.97 |
| C18 | Set of 3 genes | 6 | 100 | 99.97 |
| O26:H11 | Set of 6 genes | 204 | 100 | 99.41 |
| O103:H2 | Set of 4 genes | 121 | 100 | 99.87 |
| O111:H8 | Set of 3 genes | 96 | 100 | 100 |
| O45:H2 (C2) | Set of 5 genes | 22 | 100 | 99.97 |
| O45:H2 (C3) | Set of 3 genes | 1 | 100 | 100 |
| O118/O156:H16 | Set of 4 genes | 17 | 100 | 99.94 |
| O123/O186:H2 | Set of 3 genes | 21 | 100 | 100 |
*The specificity of cluster-specific gene set less than 100% was due to at least one false positive found in that set.