Table 3.

Comparison of 90-Day Mortality and Ventilator-Free Days Censored at Day 90 in the COVID-19–related ARDS Classes and ARDS Subphenotypes

	COVID-19–related ARDS			ARDS Subphenotypes
	Class 1 (n = 373)	Class 2 (n = 110)	P Value	Hypo (n = 341)	Hyper (n = 142)	P Value
Mortality Day 90	178 (48)	82 (75)	<0.0001	166 (49)	94 (66)	0.0006
Mortality Day 180	182 (49)	83 (75)	<0.001	170 (50)	95 (67)	0.0010
VFD	0 (0–68)	0 (0–1)	<0.0001	0 (0–67)	0 (0–45)	0.0003

Definition of abbreviations: ARDS = acute respiratory distress syndrome; COVID-19 = coronavirus disease; Hyper = hyperinflammatory subphenotype; Hypo = hypoinflammatory subphenotype; VFD = ventilator-free days.

P value for mortality represents the Pearson’s chi-square test and for VFDs represents Wilcoxon-rank test.

Data are presented as n (%) or median (interquartile range).