Table 3.

Logistic regression analysis of characteristics and outcomes associated with hypermagnesemia (n=1371)

Variable	Univariate			Multivariable
	Odds Ratio	95% Confidence Interval	P value	Odds Ratio	95% Confidence Interval	P value
Demographics
Age (per 10 years)	1.05	0.98 to 1.13	0.17	1.17	1.06 to 1.29	<0.01
Sex (reference: female)	1.90	1.47 to 2.45	<0.001	2.11	1.56 to 2.87	<0.001
Race (reference: White)a	1.32	0.99 to 1.76	0.06	1.32	0.95 to 1.85	0.10
PMHx
HTN	0.74	0.58 to 0.94	0.01	0.71	0.51 to 0.98	<0.05
DM	0.77	0.61 to 0.98	0.03	0.73	0.53 to 0.99	<0.05
ESKD	1.07	0.61 to 1.90	0.81	1.64	0.87 to 3.10	0.13
Illness severity
Pressors	1.47	1.15 to 1.89	<0.01
Mechanical ventilation	1.46	1.12 to 1.91	0.01
AKI requiring RRT	4.26	2.93 to 6.18	<0.001	3.08	1.97 to 4.81	<0.001
Labs
Any hypercalcemia, mg/dlb	1.19	0.85 to 1.66	0.31	0.88	0.59 to 1.31	0.52
Any hyperkalemia, mmol/Lc	2.19	1.72 to 2.80	<0.001	1.59	1.17 to 2.16	<0.05
Creatine phosphokinase (per 1000 U/L)	1.05	1.02 to 1.08	<0.01	1.03	1.00 to 1.06	<0.05
Lactate dehydrogenase (per 100 U/L)	1.06	1.03 to 1.08	<0.001	1.03	1.00 to 1.06	0.08
Alkaline phosphatase (per 10 U/L)	1.00	1.00 to 1.01	0.25	1.00	0.99 to 1.01	0.43
C-reactive protein (per 10 mg/L)	1.03	1.02 to 1.05	<0.001	1.01	0.99 to 1.02	0.39

PMHx, Past medical history; HTN, hypertension; DM, diabetes.

^aReference group White non-Hispanic/Latino and White Hispanic/Latino.

^bHypercalcemia defined as corrected calcium >ULN (10.3 mg/dl).

^cHyperkalemia defined as potassium >ULN (5.1 mmol/L).