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. 2021 Jul 8;2(9):1415–1423. doi: 10.34067/KID.0004402021

Figure 1.

Figure 1.

Osmotic demyelination syndrome in reported cases despite changes in serum sodium (SNa) that adhere to current hyponatremia correction guidelines. Open squares represent patients with initial SNa <115 mEq/L. Closed triangles represent patients with initial SNa ≥115 mEq/L. The dashed lines represent therapeutic limits recommended by current hyponatremia guidelines (12 mEq/L in 24 hours and 18 mEq/L in 48 hours). The case from Koul et al. (29) is not represented in this figure because changes in SNa at 24 and 48 hours were not reported. Two patients with initial SNa <115 mEq/L (John et al. [8] and Malhotra et al. [35]) corrected their SNa by 8 mEq/L and 16 mEq/L at 24 and 48 hours, respectively.