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. 2022 Jan 24;17(1):e0263080. doi: 10.1371/journal.pone.0263080

Fig 4. NOX inhibitors, SOD and catalase ameliorate endothelial dysfunction in the WTD-GS (+) group.

Fig 4

Vascular sensitivity measured under 20 mM glucose conditions was plotted as pD2 (- log of the half-maximal effective concentration [EC50]) of ACh. The control was administered to 7 rats, and other agents were administered to 4 rats each. * P < 0.05, † P < 0.01, and § P < 0.001 compared with the control in the WTD-GS (+) group, Dunnett’s test. The data are presented as the means ± SEM. Indomethacin, a cyclooxygenase inhibitor; allopurinol, a xanthine oxidase inhibitor; apocynin, a NADPH oxidase (NOX) inhibitor; GKT137831, a NOX1 and 4 inhibitor; GSK2795039, a NOX2 inhibitor; SOD, superoxide dismutase; Mito-TEMPO, a mitochondria-targeted superoxide scavenger; MnTABP, a superoxide dismutase mimetic and peroxynitrite selective scavenger; CD, control diet; WTD, Western-type diet; GS, glucose spike.