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. 2022 Jan 24;2022(1):CD013736. doi: 10.1002/14651858.CD013736.pub2

Comparison 1. Cuffed (inflated or not) versus uncuffed endotracheal tube (ETT).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Stridor 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.2 Stridor 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.03 [‐0.11, 0.18]
1.3 Subglottic stenosis 1 69 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.4 Subglottic stenosis 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.00 [‐0.06, 0.06]
1.5 Racemic epinephrine for stridor 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.27 [0.01, 6.49]
1.6 Racemic epinephrine for stridor 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.03 [‐0.11, 0.05]
1.7 Systemic steroid for stridor 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 3.26 [0.38, 27.72]
1.8 Systemic steroid for stridor 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.07 [‐0.04, 0.19]
1.9 Reintubation for stridor or subglottic stenosis 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.27 [0.01, 6.49]
1.10 Reintubation for stridor or subglottic stenosis 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.03 [‐0.11, 0.05]
1.11 Endoscopy for stridor or subglottic stenosis 1 69 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.12 Endoscopy for stridor or subglottic stenosis 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.00 [‐0.06, 0.06]
1.13 Surgical intervention (e.g. endoscopic balloon dilation, cricoid split, tracheostomy) for stridor or subglottic stenosis 1 69 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.14 Surgical intervention (e.g. endoscopic balloon dilatation, cricoid split, tracheostomy) for stridor or subglottic stenosis 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.00 [‐0.06, 0.06]
1.15 Reintubation for inadequate ETT size 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.04 [0.00, 0.64]
1.16 Reintubation for inadequate ETT size 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.32 [‐0.49, ‐0.16]
1.17 Reintubation for any reason 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.06 [0.01, 0.45]
1.18 Reintubation for any reason 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.39 [‐0.57, ‐0.21]
1.19 Accidental extubation 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.82 [0.12, 5.46]
1.20 Accidental extubation 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.01 [‐0.12, 0.10]
1.21 Ventilator‐associated pneumonia 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.27 [0.01, 6.49]
1.22 Ventilator‐associated pneumonia 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.03 [‐0.11, 0.05]
1.23 Air leak around the ETT (greater than accepted by the author) 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [0.93, 2.16]
1.24 Air leak around the ETT (greater than accepted by the author) 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.20 [‐0.03, 0.43]
1.25 Pneumothorax 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 0.27 [0.01, 6.49]
1.26 Pneumothorax 1 69 Risk Difference (M‐H, Fixed, 95% CI) ‐0.03 [‐0.11, 0.05]
1.27 Length of stay 1 69 Mean Difference (IV, Fixed, 95% CI) 0.40 [‐7.42, 8.22]
1.28 All‐cause neonatal mortality 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 2.46 [0.10, 58.39]
1.29 All‐cause neonatal mortality 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.03 [‐0.05, 0.10]
1.30 All‐cause mortality during initial hospitalization 1 69 Risk Ratio (M‐H, Fixed, 95% CI) 2.46 [0.10, 58.39]
1.31 All‐cause mortality during initial hospitalization 1 69 Risk Difference (M‐H, Fixed, 95% CI) 0.03 [‐0.05, 0.10]