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. Author manuscript; available in PMC: 2022 Jan 24.
Published in final edited form as: J Cell Signal. 2021;2(3):206–211. doi: 10.33696/signaling.2.052

Figure 2: Models for H2O2-induced cell death in cells of leukocytic lineage and in other cells.

Figure 2:

In cells of leukocytic lineage such as HAP1 cells, H2O2 cell entry is riboflavin-mediated. H2O2 enters the cell through an aquaporin and through mediators of redox biology, riboflavin metabolism, iron homeostasis, vesicle trafficking, and the peroxisomal import pathway, cell death occurs. In cells that are not of leukocytic lineage, riboflavin does not mediate H2O2 cell entry.