Figure 9 -.
Experimentally measured effects of RBD mutations on binding of monoclonal antibodies at sites that differ between the BA.1 lineage viruses and Wuhan-Hu-1. The line plot shows antibody binding escape measured by deep mutational scanning of the Wuhan-Hu-1 RBD16, averaged across 36 monoclonal antibodies (8 class 1, 13 class 2, 7 class 3, and 8 class 4 antibodies). Sites that are mutated in the BA.1 relative to Wuhan-Hu-1 are indicated and colored according to the predicted antigenic effect of mutations at that site (strong, moderate, or minimal). An interactive version of this plot is available at https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/.