Table 1.
Clinical Characteristics of Patients with Detected Blocking Anti-Cytokine Antibodies.
| Patient ID | Infection | Blocking ACA | Binding ACA | Age | Sex | Comorbidities | Status | Other |
|---|---|---|---|---|---|---|---|---|
| UMR15 | Influenza | IFNα2 | IFNα2, IFNα8, IFNα10 | 66 | M | COPD, arterial hypertension, chronic heart disease | Alive | Two years after developing influenza, developed severe COVID-19 ARDS two weeks after the first Biontech mRNA vaccination, with re-activation of CMV and HSV-pneumonitis Slightly elevated CRP, normal total leukocytes, lymphopenia Vaccinated for flu in 2Ol8 |
| UMR12 | Influenza | GM-CSF | IFNα7, GM-CSF, sRANK-ligand | 86 | F | No significant medical history | Alive | Elevated CRP, leukopenia, normal lymphocyte percentage Not vaccinated for flu |
| AA9 | Influenza A H3 | IFNα2 | IFNα1, IFNα2, IFNα7, IFNα8, IFNα10, IFNω, IL-11 | 73 | M | COPD, sleep-breathing disorder, cardiovascular disease, heart failure, hypertension, dyslipidemia | Discharged | Ex-smoker Fever, rigor productive cough, bilateral lung infiltrates Not vaccinated for flu |
| AA20 | Influenza A H3 | IL-6 | IL-6 | 77 | F | Obesity, hypertension, atrial fibrillation, COPD | Discharged | Smoker Fever, productive cough, bilateral lung infiltrates Vaccinated for flu |
| SU107 | Serratia bacteremia | IFNα2 | IFNα1, IFNα2, IFNα7, IFNα8, IFNα10, IFNλ3, IFNω, IL-12p70 | 69 | M | N/A | Alive | Intubated |
| SU019 | Clinically suspected bacterial infection | GM-CSF | IFNα6, IFNα6, GM-CSF | 70 | F | N/A | Alive | Back/costovertebral angle tenderness, sepsis, dysuria Not intubated |
| SU047 | MSSA pneumonia | IFNλ2, IFNλ3 | IFNλ2, IFNλ3 | 69 | M | Recurrent cholangitis | Alive | Following insulinoma resection, developed leukocytosis and worsening respiratory distress, requiring intubation. Bronchoscopy showed MSSA Pneumonia. Survived after l month in the hospital, but required several readmissions for recurrent VRE retroperitoneal abscesses (now resolved) |
| SU008 | RSV | IFNα7 | IFNα7, IFNα8, IFNα10 | 63 | F | N/A | Alive | Fever, leukocytosis, acute respiratory failure Not intubated |
| SU042 | None reported | IL-6 | IFNα7, IL-4, IL-6, IL-17F, MIP-1α | 84 | F | N/A | Alive | Not intubated |
| SU080 | Clostridioides difficile | GM-CSF | IFNα10, GM-CSF | 60 | F | N/A | Alive | Shock Not intubated |
| UGMLC5 | Suspected bacterial infection, pathogen not detected | IFNα8 | IFNα7, IFNα8, IFNα10 | 69 | M | N/A | N/A | Pneumonia-induced ARDS |