Table 1:

Demographic details of the 3 cohorts. Age (ANOVA or unpaired t-test), gender, and comorbidities distribution) were compared across disease diagnosis and severity subgroups using Chi-square test.

			Non-COVID-19				COVID-19
			Negative Control		Positive Control			Critical
			HC	Acute	MS, Non-Active	MS, Active	Moderate	Survived	Died
	n		58	10	35	35	10	10	10
Cohort 1	Age (years)	mean (SD)	41.1 (13.7)	43.6 (20.8)	52.8 (11.3)*	37.6 (10.8)	51.8 (13.9)	56.1 (11.4)*	69.4 (11.7)*
(N = 168)	Gender	female (%)	28 (48.3)	2 (20.0)	16 (45.7)	22 (62.9)	3 (30.0)	2 (20.0)	1 (10.0)*
	Comorbidities	yes (%)	NA	7 (70.0)	NA	NA	8 (80.0)	7 (70.0)	9 (90.0)
	n		18	-	-	-	-	10	10
Cohort 2	Age (years)	mean (SD)	44.1 (10.5)	-	-	-	-	64.7 (9.9)*	67.0 (6.9)*
(N = 38)	Gender	female (%)	9 (50.0)	-	-	-	-	5 (50.0)	0 (0.0)*#
	Comorbidities	yes (%)	NA	-	-	-	-	6 (60.0)	10 (100.0)#
	n		-	-	-	-	-	175	113
Cohort 3	Age (years)	mean (SD)	-	-	-	-	-	73.8 (10.7)	77.3 (10.4)#
(N = 288)	Gender	female (%)	-	-	-	-	-	40 (22.8)	35 (30.9)
	Comorbidities	yes (%)	-	-	-	-	-	123 (70.3)	87 (76.9)

^*p < 0.05 vs HC and

^#p < 0.05 vs COVID-19, Critical - Survived.