Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 22;54(1):314–325. doi: 10.1080/07853890.2021.1995624

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — PPI network analysis of module genes identifies key genes. (A). Top 100 most connected genes in the PPI network. The larger the node, the greater the degree. (B). Selection of optimal parameter (λ) in the LASSO model. The log(λ) value of 12 is used for further analysis. (C) LASSO coefficient profiles of 12 signature genes. (D) AUC values of the signature genes in the training set. (E) AUC values of the signature genes in the validation set. (F) AUC values of the signature genes in GPL10558. (G) AUC values of important genes. (H) Expression levels of PSMB8 and IFI27 in ART or HIV-positive individuals of GPL6947. (I) Relative expression levels of PSMB8 and IFI27 in blood samples of controls, HIV-positive individuals, and ART patients detected by qRT-PCR. **p Value <.01. Ctrl: controls; ART: antiretroviral therapy. (J) Correlations between key genes and clinical features.