Fig. 5.
RNAi-mediated knockdown of the JADE1 ortholog rhinoceros (rno) enhances tau-induced toxicity in Drosophila. a–e Scanning electron micrograph images showing rnoRNAi significantly enhances the tau-induced rough eye phenotype (size, roughness, shape, and conical shape, p = 8.7 × 10−5, n = 16 per genotype). Scale bar 100 μm. f–j RnoRNAi significantly increases the number of terminal deoxynucleotidyl transferase dUTP nick end-labels (TUNEL) in tau transgenic Drosophila compared to tau expressed alone (p = 0.008, n = 6 per genotype). TUNEL was performed at day 10 of adulthood and quantified in the entire fly brain. Representative images are shown from the cortex. An equal number of male and female flies were used for each experiment