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. Author manuscript; available in PMC: 2022 Jan 24.
Published in final edited form as: Acta Neuropathol. 2021 Nov 1;143(1):33–53. doi: 10.1007/s00401-021-02379-z

Table 2.

Associations with Braak stage in PART (p < 5.0E − 06, n = 647)

Chr Base pair SNP Genes A1 Beta SE L95 U95 t statistic p
2 11,935,322 rs78580932 GREB1, NTSR2, LPIN1, MIR4262 C − 0.54 0.10 −0.76 −0.34 −5.15 3.55E-07
2 235,768,810 rs74600760 ARL4C, SH3BP4 T − 0.53 0.11 −0.74 −0.32 −4.86 1.48E-06
3 61,518,166 rs111610564 FHIT, PTPRG C − 0.49 0.10 −0.70 −0.30 −4.82 1.81E-06
3 140,216,029 rs349509 CLSTN2, CLSTN2-AS1, TRIM42 A − 0.77 0.16 −1.08 −0.47 −4.97 8.64E-07
3 179,019,705 rs13323081 PIK3CA, KCNMB3, ZNF639, MFN1 G 0.24 0.05 0.15 0.33 5.17 3.16E-07
4 130,085,480 rs56405341 C4orf33, SCLT1, JADE1 A 0.25 0.05 0.16 0.35 5.52 4.82E-08
4 137,329,297 rs77506227 A − 0.79 0.16 −1.12 −0.48 −4.88 1.34E-06
5 150,473,104 rs6579838 GPX3, TNIP1, ANXA6 C 0.23 0.05 0.14 0.32 5.10 4.57E-07
10 124,487,608 rs150945906 DMBT1, C10orf120, DMBT1P1 A − 0.64 0.14 −0.91 −0.38 −4.77 2.31E-06
15 24,515,682 rs147462127 PWRN2, PWRN1 T − 0.84 0.17 −1.18 −0.51 −4.98 8.37E-07
15 36,865,219 rs185845364 C15orf41, CSNK1A1P1 G − 0.79 0.16 −1.11 −0.48 −4.94 9.79E-07
17 1,879,293 rs12946465 RPA1, RTN4RL1, DPH1, OVCA2 C − 0.21 0.05 −0.31 −0.13 −4.75 2.51E-06
19 45,719,790 rs10415392 TRAPPC6A, BLOC1S3, EXO3L2, MARK4 T 0.34 0.07 0.21 0.48 4.85 1.59E-06
20 56,754,110 rs78923929 C20orf85, PPP4R1L, RAB22A A − 0.65 0.13 −0.92 −0.40 −4.95 9.76E-07

Genome-wide significant difference in bold, chr = chromosome, SNP = single nucleotide polymorphism, SE = standard error