Table 3.
Significant overlapping PART genetic associations with AD and PSP
| Associated disease | Chr | Base pair | SNP | Gene | A1 | Beta | SE | L95 | U95 | t statistic | p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AD | 14 | 92,938,855 | rs12590654 | SLC24A4 | A | − 0.14 | 0.044 | −0.23 | −0.05 | −3.19 | 0.0015 |
| AD | 11 | 60,021,948 | rs1582763 | MS4A6A | A | − 0.11 | 0.044 | −0.19 | −0.02 | −2.47 | 0.0138 |
| AD | 11 | 59,958,380 | rs2081545 | MS4A6A | A | − 0.10 | 0.044 | −0.19 | −0.02 | −2.36 | 0.0185 |
| AD | 4 | 11,723,235 | rs7657553 | HS3ST1 | A | 0.11 | 0.048 | 0.01 | 0.20 | 2.24 | 0.0255 |
| PSP | 17 | 44,019,712 | rs242557 | MAPT | A | 0.10 | 0.047 | 0.01 | 0.20 | 2.24 | 0.0256 |
| AD | 11 | 59,942,815 | rs7935829 | MS4A6A | G | − 0.10 | 0.043 | −0.18 | −0.01 | −2.21 | 0.0274 |
| PSP | 2 | 88,895,351 | rs7571971 | EIF2AK3 | T | − 0.10 | 0.047 | −0.19 | −0.01 | −2.09 | 0.0373 |
AD = Alzheimer disease, PSP = progressive supranuclear palsy, Chr = chromosome, SNP = single nucleotide polymorphism