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. 2021 Dec 31;2021(12):CD003453. doi: 10.1002/14651858.CD003453.pub2

NCT02996292.

Methods Setting: Syrian Arab Republic
Design: 3‐arm parallel RCT
No. of centres: unclear
Study duration: unclear
Participants Age 14‐24 years
Inclusion criteria:
  • Permanent dentition stage

  • Crowding up to 6 mm

  • Class I relationship

  • Good oral hygiene


Exclusion criteria:
  • Poor oral hygiene

  • Previous orthodontic treatment

  • Patients with syndromes, clefts, or craniofacial abnormalities

  • Class II or III skeletal anteroposterior relationship

  • Crowding < 3 mm and > 6 mm

Interventions Orthodontic intervention: fixed appliances
Conventional brackets versus active self‐ligating brackets versus passive self‐ligating brackets
Outcomes Primary outcome: speed of alignment
Secondary outcomes:
  • Changes of the torque and tipping of teeth

  • Changes of widths and depths of the dental arches

  • External apical root resorption

Notes Emailed author; awaiting contact