NCT04347018.

Study name	NCT04347018
Methods	Setting: unclear Design: parallel RCT (2 arms) No. of centres: unclear Study duration: unclear
Participants	Inclusion criteria Unclear if it is 10‐18 years old or 10‐17 years old Angle Class I and Cl II (up to half cusp) molar and canine relationship Fully erupted permanent dentition (excluding third molars) Crowding of ≤ 7 mm Must be able to maintain good oral hygiene assessed by the orthodontist during their visits Exclusion criteria Previous history of orthodontic treatment or orthognathic surgery Subjects who require extractions or orthognathic surgery Multiple missed appointments Deteriorating oral hygiene and craniofacial syndromes or disorders Severe gag reflex resulting from the use of intra‐oral scanners
Interventions	Orthodontic intervention: fixed appliances BRIUS appliance versus preadjusted edgewise full fixed appliance
Outcomes	Primary outcome: Little's Irregularity Index Secondary outcomes: pain and discomfort
Starting date	July 2020
Contact information	malzaina@buffalo.edu
Notes	Emailed study author for further information