Figure 3. mTORC1 translational control and its link to the aged cell phenotype.

Highlighted factors (blue) are more abundant in the aged cells and enhance overall translation, with some specific stimulatory effects on mRNAs with 5′ Terminal Oligopyrimidine (TOP) tracts and long-and-structured (highly cap-and-scanning-dependent) 5′UTRs (red arrows) [88,89,92].