Table 1.
Characteristics and Bivariate Odds Ratios in Venous Thromboembolism (VTE) Cases and Matched Controls: Asthma Patients Aged 20–59 Years in CPRD GOLD 1995–2015
| Cases (n=1168) | Controls (n=4672) | OR | 95% CI | |
|---|---|---|---|---|
| Age at Index Date (years) | ||||
| 20–29 | 86 (7.4) | 344 (7.4) | NAa | NAa |
| 30–39 | 207 (17.7) | 828 (17.7) | NAa | NAa |
| 40–49 | 284 (24.3) | 1136 (24.3) | NAa | NAa |
| 50–59 | 591 (50.6) | 2364 (50.6) | NAa | NAa |
| Sex | ||||
| Male | 483 (41.4%) | 1932 (41.4%) | NAa | NAa |
| Female | 685 (58.7%) | 2740 (58.7%) | NAa | NAa |
| BMI (kg/m2) | ||||
| <18 | 11 (0.9%) | 48 (1.0%) | 1.4 | 0.7–2.8 |
| 18–24 | 241 (20.6%) | 1526 (32.7%) | 1.0 (reference) | 1.0 (reference) |
| 25–30 | 289 (24.7%) | 1357 (29.1%) | 1.4 | 1.1–1.7 |
| >30 | 532 (45.6%) | 1284 (27.5%) | 2.7 | 2.3–3.2 |
| Unknown | 95 (8.1%) | 457 (9.8%) | 1.3 | 1.0–1.7 |
| Smoking Status | ||||
| Non-smoker | 490 (42.0%) | 2219 (47.5) | 1.0 (reference) | 1.0 (reference) |
| Current smoker | 286 (24.5%) | 989 (21.2) | 1.3 | 1.1–1.5 |
| Past-smoker | 361 (30.9%) | 1342 (28.7) | 1.2 | 1.0–1.4 |
| Unknown | 31 (2.7%) | 122 (2.6) | 1.1 | 0.7–1.8 |
| Comorbidities | ||||
| Phlebitis | 101 (8.7%) | 66 (1.4) | 6.8 | 4.9–9.4 |
| Hypertension | 196 (16.8%) | 842 (18.0) | 0.9 | 0.8–1.1 |
| Diabetes | 69 (5.9%) | 189 (4.1) | 1.5 | 1.1–2.0 |
| Hyperlipidemia | 96 (8.2%) | 495 (10.6%) | 0.7 | 0.6–0.9 |
| Alcohol abuse | 14 (1.2%) | 48 (1.0%) | 1.2 | 0.6–2.1 |
| COPD | 114 (9.8%) | 327 (7.0%) | 1.5 | 1.2–1.9 |
| Epilepsy | 6 (0.5%) | 15 (0.3%) | 1.6 | 0.6–4.1 |
| Other Proximate Causes of VTE within 90 Days | ||||
| HRT or OC useb | 123 (10.5%) | 382 (8.2%) | 1.4 | 1.1–1.7 |
Notes: aMatching factor; bAmong women only.
Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; NA, not applicable; HRT, hormone replacement therapy; OC, oral contraceptive.