Table 3.

The Association Between Any Glucocorticoid Exposure and VTE for Asthma Patients Aged 20–59 Years in CPRD 1995–2015 (n=5840)

Odds Ratio (95% Confidence Interval) for Venous Thromboembolism (VTE)
	Cases/Controls	Model 1a OR (95% CI)	Model 2b OR (95% CI)	Model 3c OR (95% CI)
Exposure Status
Unexposed	296/1763	1.0 (reference)	1.0 (reference)	1.0 (reference)
Exposed	872/2909	1.8 (1.6–2.1)	1.7 (1.5–2.0)	1.7 (1.5–2.0)
Recency
Unexposed	296/1763	1.0 (reference)	1.0 (reference)	1.0 (reference)
Current	670/1992	2.1 (1.8–2.5)	1.9 (1.6–2.3)	1.9 (1.6–2.3)
Recent	118/495	1.4 (1.1–1.8)	1.4 (1.1–1.8)	1.4 (1.1–1.8)
Past	84/422	1.2 (0.9–1.6)	1.2 (0.9–1.6)	1.2 (0.9–1.5)
Route of Exposure
Unexposed	296/1763	1.0 (reference)	1.0 (reference)	1.0 (reference)
Systemic	171/281	3.8 (3.0–4.8)	3.5 (2.7–4.5)	3.5 (2.7–4.5)
Inhaled	701/2628	1.6 (1.4–1.9)	1.5 (1.3–1.8)	1.5 (1.3–1.8)

Notes: ^aUnadjusted. ^bAdjusted for phlebitis, COPD, diabetes, BMI, smoking. Conditional on the matching factors. ^cAdjusted for phlebitis, COPD, diabetes, BMI, smoking, hormone replacement/OCP, epilepsy, alcohol. Conditional on the matching factors. Exposed = glucocorticoid use less than 1 year prior to the index date. Unexposed = glucocorticoid use 1 year or more prior to the index date; Current use = glucocorticoid use less than 90 days prior to the index date; Recent use = glucocorticoid use 90 days–less than 180 days prior to the index date; Past use = glucocorticoid use 180 days–less than 1 year prior to the index date.

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.