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. 2022 Jan 17;2022:9369035. doi: 10.1155/2022/9369035

Figure 2.

Figure 2

lncRNA IGF2-AS played a regulatory role by binding HMGA1. (a) Starbase predicted binding sites of lncRNA IGF2-AS to HMGA1. (b) RIP experiment verified the binding of lncRNA IGF2-AS to HMGA1. (c, d) qRT-PCR and WB were utilized to measure HMGA1 expression in EPCs of sepsis patients. (e) Pyroptosis of EPCs was detected by TEM. (f, g) qRT-PCR and WB were performed to verify HMGA1 interference efficiency and detect pyroptosis-related factors ASC, Caspase-1, NLRP3, and IL-18 expressions. (h) Expression of HMGA1 was detected by qRT-PCR. ∗P < 0.05 vs. Healthy or si-NC.