Table 2.
Fasting glucose, insulin, and HOMA-IR profiles in different study groups.
Variables | Control group | T2DM group | AD-MSCs group | AD-MSCs pretreated with OXA group |
---|---|---|---|---|
Fasting glucose (mmol/l) | 6.1 ± 0.16 | 17.5 ± 3.1a | 9.6 ± 1.2abc | 7.1 ± 0.64b |
Insulin (mU/l) | 8.1 ± 0.10 | 18.4 ± 1.1a | 11.8 ± 1.2abc | 9.7 ± 0.46ab |
HOMA-IR | 2.2 ± 0.11 | 14.3 ± 2.7a | 5.1 ± 1.2abc | 3.1 ± 0.44b |
The results are reported as mean ± SD; n = 7 each. pa < 0.001 as compared to the control group, pb < 0.001 as compared to the T2DM group, and pc < 0.001 as compared to AD-MSCs pretreated with the OXA group. T2DM group/T2DM: type 2 diabetes; AD-MSCs: adipose-derived mesenchymal stem cells; OXA: orexin A; HOMA-IR: homeostatic model assessment of insulin resistance index. The significance level was set at p < 0.05.