Table 3.
Levels of glucose uptake, lipid profile, and inflammatory markers in different study groups.
| Variables | Control group | T2DM group | AD-MSCs group | AD-MSCs pretreated with OXA group |
|---|---|---|---|---|
| Glucose uptake | ||||
| Muscle (mg/g tissue/h) | 8.57 ± 0.22 | 4.53 ± 0.19a | 6.5 ± 0.16abc | 8.31 ± 0.132b |
| Adipose tissue (mg/g tissue/h) | 9.67 ± 0.182 | 3.73 ± 0.182a | 7.64 ± 0.214abc | 9.34 ± 0.25b |
| Lipid profile | ||||
| Triglycerides (mg/dl) | 75.5 ± 2.6 | 118.9 ± 6.9a | 92 ± 7.8abc | 82.4 ± 6.2b |
| Total cholesterol (mg/dl) | 136.5 ± 0.524 | 259.7 ± 1.07a | 185.41 ± 0.917abc | 137.56 ± 0.725b |
| HDL (mg/dl) | 59.75 ± 0.717 | 27.85 ± 0.723a | 41.11 ± 0.56abc | 58.75 ± 0.55b |
| Inflammatory markers | ||||
| TNF-α (pg/ml) | 15.16 ± 0.35 | 92.2 ± 0.74a | 52.58 ± 0.312abc | 15.8 ± 0.419b |
| IL-6 (pg/ml) | 30.73 ± 0.319 | 115.21 ± 0.69a | 68.25 ± 0.725abc | 31.58 ± 0.453b |
The results are reported as mean ± SD; n = 7 each. pa < 0.001 as compared to the control group, pb < 0.001 as compared to the T2DM group, and pc < 0.001 as compared to AD-MSCs pretreated with the OXA group. T2DM group/T2DM: type 2 diabetes; AD-MSCs: adipose-derived mesenchymal stem cells; OXA: orexin A. The significance level was set at p < 0.05.