Table 5.
Pharmacokinetic parameters of trans-resveratrol and its metabolites in mice after a single intragastric administration of trans-resveratrol at a dosage of 150 mg kg−1 (n = 6).
| Analytes | Parameters (mean ± SD) | ||||
|---|---|---|---|---|---|
| AUC(0–12) (ng·h mL−1) | AUC(0–∞) (ng·h mL−1) | C max (ng mL−1) | T max (h) | t1/2 (h) | |
| Trans-resveratrol | 8335.03 ± 4980.70 | 8463.70 ± 5000.20 | 5969.17 ± 3838.91 | 0.5 ± 0.282 | 1.90 ± 1.23 |
| R3G | 51027.06 ± 30317.97 | 53016.13 ± 30991.44 | 13799.17 ± 7070.70 | 0.77 ± 0.46 | 2.24 ± 1.04 |
| R3S | 3083.44 ± 1625.43 | 3163.12 ± 1624.85 | 971.75 ± 485.22 | 0.60 ± 0.27 | 2.08 ± 0.86 |
R3G, trans-resveratrol-3-o-β-glucuronide; R3S, trans-resveratrol-3-sulfate salt; AUC(0-12), area under the plasma concentration-time curve from 0 to 12 hours; AUC(0–∞), area under the plasma concentration-time curve from 0 to infinity hours; Tmax, time to peak concentration; Cmax, maximal concentration; t1/2, eliminate half-life.