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. 2022 Jan 25;185(6):1025–1040.e14. doi: 10.1016/j.cell.2022.01.018

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© 2022 The Authors

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Figure S3 — BNT162b2 vaccination produces less broad serological responses to endemic human coronaviruses (HCoVs) compared with SARS-CoV-2 infection, related to Figure 2

(A and B) Anti-SARS-CoV-1 spike and anti-HCoV-OC43, -HKU1, -NL63, and -229E spike IgM, IgG, and IgA antibody responses are shown for individuals who received BNT162b2 prime (D0) and boost (D21) vaccination doses and for COVID-19 patients. (A) The heatmap shows the development of antibody responses in longitudinal samples from vaccinees/patients collected at/during D0, D7/week 1, D21/weeks 2 and 3, D28/week 4, D42/weeks 5 and 6, and D90/≥week 7 after vaccination/COVID-19 symptom onset (x axis). The color scale encodes the median values of log₁₀ MSD AU/mL concentrations. (B) Box-whisker plots show the development of antibody responses in longitudinal samples from vaccinees/patients collected at/during D0, D7/week 1, D21/weeks 2 and 3, D28/week 4, D42/weeks 5 and 6, and D90/≥week 7 after vaccination/COVID-19 symptom onset (x axis). Box-whisker plots show the interquartile range as the box and the whisker ends as the most extreme values within 1.5 times the interquartile range below the 25% quantile and above the 75% quantile. Statistical test: pairwise Wilcoxon rank sum test with Bonferroni correction. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. Individuals were classified as vaccinees who have not been previously exposed to SARS-CoV-2 (vaccinees), outpatients (Outpt) and hospital-admitted patients (Admit), and ICU patients and those who died from their illness (Death).

(C) Box-whisker plots show anti-SARS-CoV-1 spike and anti-HCoV spike antibody responses in plasma samples from individuals who received BNT162b2 prime (D0, n = 59 individuals), second dose (D21, n = 58 individuals), and third dose (around month 9, n = 36 individuals) vaccination. Box-whisker plots show the interquartile range as the box and the whisker ends as the most extreme values within 1.5 times the interquartile range below the 25% quantile and above the 75% quantile.