Figure S4.

Pathway analysis of patient-group-specific transcriptomic signatures in CD8⁺ T and CD4⁺ T cell, monocytes, and B cells across time and patient cohorts, related to Figure 5

Two pathways are shown for each cell types. Left two boxplots for each pathway indicate the enrichment score of a specific pathway across the four patient groups at T1 and T3. Unexposed healthy controls and deceased patients are also included as comparisons (see color key at bottom). The right two projections for each pathway color code the pathway-enrichment score for each blood draw onto their respective dots (each dot represents a patient blood draw) on the map of Figure 5B for INCOV (upper) and HAARVI (lower) cohorts. p values calculated from the Mann-Whitney U test are displayed in asterisks if <0.05. ∗p value < 0.05, ∗∗p value < 0.01, ∗∗∗p value < 0.001, and ∗∗∗∗p value < 0.0001.