Figure S5.

Clinical and functional characteristics of patient groups and dimensional projection validity, related to Figure 5

(A) Bar plots showing the time between onset of COVID-19 to each of the blood draws across four patient groups. Data are represented as mean ± SE. FDR are displayed. No significant differences are seen.

(B) Boxplot showing patient age upon enrollment. FDR are displayed. p values calculated from the Mann-Whitney U test then corrected as FDR via the Benjamin-Hochberg method are displayed in asterisks if FDR < 0.05. ∗FDR < 0.05, ∗∗FDR < 0.01, ∗∗∗FDR < 0.001, and ∗∗∗∗FDR < 0.0001.

(C) Bar plot showing days in hospitals across patient groups. Data are represented as mean ± SE. FDR are displayed. p values calculated from the Mann-Whitney U test then corrected as FDR via the Benjamini-Hochberg method are displayed in asterisks if FDR < 0.05. ∗FDR < 0.05, ∗∗FDR < 0.01, ∗∗∗FDR < 0.001, and ∗∗∗∗FDR < 0.0001.

(D) Dimension reduction visualization from Figure 5 with INCOV and HAARVI cohorts overlayed and colored by their respective definitions and measurements of disease severity. Immune endotypes are circled.

(E) Boxplot showing somatic hypermutation (SHM) rates in memory B cells (upper left), percentages of IGHG1 (upper middle) and IGHM (upper right) memory B cell clones over all memory B cell clones, and RBD (lower left), spike (lower middle), and nucleocapsid (lower right) IgG log₁₀(titers) for patients at T3. ∗p value < 0.05, ∗∗p value < 0.01, ∗∗∗p value < 0.001, and ∗∗∗∗p value < 0.0001.

(F) Boxplot showing the dimension-1 (y axis of top row) and dimension-2 (y axis of bottom row) values of four patient groups controls across time points in comparison with dead patients and unexposed healthy. p values calculated from Mann-Whitney U test are displayed in asterisks if <0.05. ∗p value < 0.05, ∗∗p value < 0.01, ∗∗∗p value < 0.001, and ∗∗∗∗p value < 0.0001.