TABLE 3.
Risk factors for overall survival
| Factors | N = 203 | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
| 5Y‐survival | P value | HR | 95% CI | P value | ||
| Age (y) | ||||||
| ≥65 | 129 | 72.3% | .21 | |||
| <65 | 74 | 74.5% | ||||
| Gender | ||||||
| Male | 157 | 73.6% | .62 | |||
| Female | 46 | 72.1% | ||||
| Hepatitis virus | ||||||
| Nonvirus | 66 | 68.9% | .14 | |||
| HCV antibody | 99 | 72.6% | ||||
| HBV antigen | 38 | 81.2% | ||||
| AAC (mm3) | ||||||
| ≥250 | 150 | 67.9% | <.01 | 2.51 | 1.24‐5.09 | .01 |
| <250 | 53 | 88.2% | ||||
| Total bilirubin (mg/dL) | ||||||
| ≥1.5 | 11 | 36.4% | <.01 | |||
| <1.5 | 192 | 75.4% | ||||
| ALT (IU/L) | ||||||
| ≥50 | 45 | 79.4% | .25 | |||
| <50 | 158 | 71.3% | ||||
| Albumin (mg/dL) | ||||||
| ≥4.0 | 121 | 81.4% | <.01 | 1.98 | 1.21–3.22 | <.01 |
| <4.0 | 82 | 59.6% | ||||
| PT (%) | ||||||
| ≥80 | 154 | 72.2% | .70 | |||
| <80 | 49 | 76.3% | ||||
| ICG‐R15 (%) | ||||||
| ≥10 | 130 | 68.6% | .04 | |||
| <10 | 73 | 81.2% | ||||
| Operation time (min) | ||||||
| ≥360 | 76 | 61.7% | <.01 | |||
| <360 | 127 | 77.8% | ||||
| Blood loss (mL) | ||||||
| ≥400 | 75 | 73.2% | <.01 | 1.64 | 1.01–2.67 | .04 |
| <400 | 128 | 81.2% | ||||
| DCP (mAU/mL) | ||||||
| ≥40 | 114 | 66.3% | .06 | |||
| <40 | 89 | 81.8% | ||||
| AFP (ng/mL) | ||||||
| ≥40 | 60 | 60.0% | .03 | 2.49 | 1.48–4.17 | <.01 |
| <40 | 143 | 78.8% | ||||
| Child–Pugh | ||||||
| Class A | 190 | 73.6% | .06 | |||
| Class B | 13 | 66.6% | ||||
| Anatomical hepatectomy | ||||||
| Yes | 57 | 82.5% | .08 | |||
| No | 146 | 69.5% | ||||
| Hepatectomy | ||||||
| Minor hepatectomy | 175 | 77.8% | <.01 | |||
| Major hepatectomy | 28 | 44.6% | ||||
| Number of tumor | ||||||
| ≥2 | 64 | 53.6% | <.01 | 2.15 | 1.30–3.57 | <.01 |
| <2 | 139 | 82.3% | ||||
| Tumor size (mm) | ||||||
| ≥40 | 58 | 51.7% | <.01 | 1.92 | 1.17–3.15 | <.01 |
| <40 | 145 | 82.1% | ||||
| Poorly differentiated | ||||||
| Yes | 20 | 56.3% | .02 | |||
| No | 183 | 74.9% | ||||
| Vascular invasion | ||||||
| Yes | 39 | 50.2% | <.01 | |||
| No | 164 | 78.1% | ||||
| Serosal invasion | ||||||
| Yes | 28 | 66.5% | .30 | |||
| No | 175 | 74.2% | ||||
Abbreviations: ACC, abdominal aortic calcification; AFP, a‐fetoprotein; ALT, alanine aminotransferase; DCP, des‐gamma‐carboxy protein; HCC, hepatocellular carcinoma; HCV, hepatitis virus type C; ICGR‐15, indocyanine green clearance test; PT, prothrombin time.