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. 2022 Jan 11;9:709669. doi: 10.3389/fcell.2021.709669

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Copyright © 2022 Chen, Long, Zhu, Yang, Qiu, Zhao, Liu, Tao, Zhang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DNA methylation-driven gene for predictive signature and corresponding survival analysis. (A) Filtration of the optimal number of DNA methylation-driven genes by 1,000 iterations of Cox LASSO regression with ten-fold cross-validation. (B) Ultimate four genes of nonzero coefficients are selected as candidate DNA methylation-driven genes. (C) K-M survival curves for MBOAT2 and OAS2 of which the expression was negatively correlated with OS in PC patients. (D) K-M survival curves for RIC3 and SEZ6L of which the expression was positively correlated with OS in PC patients. LASSO, least absolute shrinkage and selection operator; K-M, Kaplan–Meier; OS, overall survival; PC, pancreatic cancer.