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. 2021 Nov 6;74(1):204–215. doi: 10.1007/s43440-021-00337-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The impact of genotype on mRNA and protein abundance of drug-metabolizing enzymes (CYP2C19, CYP3A5, CYP2D6, and UGT1A1) in all study participants (n = 24). Horizontal bars represent median values for each group. Values for mRNA are shown as relative quantity in relation to mean expression of five housekeeping genes (GAPDH, PPIA, HMBS, RPLP0, and RPS9). Significant p values are marked with asterisks (*p < 0.05; ***p < 0.001)