Table 2.

Correlation between RNA and protein abundance of CYP450 and UGT enzymes in human liver samples

mRNA vs. protein	D n = 11	M n = 13	All samples n = 24
CYP1A2	0.845**	0.775**	0.744***
CYP2B6	0.773**	0.593	0.790***
CYP2C8	0.909***	0.786**	0.790***
CYP2C9	0.764**	0.802***	0.381
CY2C19	0.601	0.884***	0.763***
CYP2D6a	0.664*	0.525	0.493*
CYP2E1	− 0.036	0.258	0.138
CYP3A4	0.845**	0.780**	0.851***
CYP3A5	0.691*	0.676*	0.744***
UGT1A1	0.609*	0.626*	0.722***
UGT1A3	0.236	0.527	0.430*
UGT2B7	0.782**	0.670*	0.799***
UGT2B15	0.355	0.813***	0.492*

Spearman coefficient values are given

M non-tumorous liver samples from patients with metastatic colon cancer, D liver samples from organ donors

*p < 0.05

**p < 0.01

***p < 0.001

^aPatient deficient for CYP2D6 (*4/*4 genotype) was excluded from analysis