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. 2021 Oct 7;59(1):17–34. doi: 10.1007/s12035-021-02566-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Western blot analysis for the relative expression of major Aβ cleaving enzymes. The relative expression of (a) α-secretase, (b) β-secretase, (c) γ-secretase [Presenilin-1 (PSEN-1); Presenilin-2 (PSEN-2); Nicastrin], (d) Plasmin, and (e) Insulin degrading enzyme (IDE) in non-demented controls, sAD and rpAD cases depicted no significant differences (n = 6–12). (f) However, the higher expression of β-secretase in comparison to α-secretase indicated differences in amyloidogenic processing between the two variants. All blots were subjected to total protein normalization. Densitometric analysis was conducted using data from three independent experiments. One-way ANOVA, followed by Tukey’s multiple comparisons test, was used for statistical analysis. Error bars represent SEM. (**p ≤ 0.01)