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. 2021 Oct 20;59(1):276–293. doi: 10.1007/s12035-021-02591-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sex-stratified cell type-specific disease signatures across brain regions. a. Upset plots indicating intersections of AD versus non-AD DEGs (BH-adjusted p value < 0.05 and absolute LFC > 0.25) within cell types across brain region and sex. Rows correspond to brain region and sex pairings. The bar chart shows the number of single and common sets of DEGs across brain regions and sex. Single filled dots represent a unique set of DEGs for the corresponding brain region and sex. Multiple filled black dots connected by vertical lines represent common sets of DEGs across brain region and sex. Bar chart colors correspond to whether DEGs are shared by brain regions or sex using the bottom right key. b. LFC scores of all genes in the DE analysis of both brain regions clustered by cell type, brain region, and sex