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. 2022 Jan 24;13:465. doi: 10.1038/s41467-022-28107-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Cartoon depicting the experimental design for the transcriptome analysis of NvLsd1 mutants. Controls are shown in green, and mutants are shown in orange. b PCA plot using the gene counts after variance stabilizing transformation (VST). Late planula samples are shown as circles and primary polyp as triangles. Experimental conditions are encoded with color: green for controls and orange for mutants. c, d MA-plots of up- and down- regulated genes between NvLsd1^−/− and control in late planula (c) and primary polyps (d). Differentially expressed genes are shown in orange at significance level of 0.05. e Venn diagram comparing all differentially expressed genes at late planula and primary polyp stages. f Venn diagram comparing genes downregulated in NvLsd1^−/− late planula and primary polyp with genes upregulated in NvNcol3::mOrange2⁺ cells. g Comparison of the overlap between up- and downregulated genes in NvLsd1^−/− late planula and primary polyps with those upregulated in NvNcol3::mOrange2⁺ and NvElav1::mOrange⁺ cells using the GeneOverlap R package. The strength of the blue color indicates the odds ratio and numbers indicate the p-value, calculated using one-sided Fisher’s exact test.