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. 2022 Jan 24;8:36. doi: 10.1038/s41420-022-00818-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The overlapping analysis of apatinib upregulated genes and neuroactive ligand associated genes. B The results of the overlapped genes in RNA-seq data. C H522, H460, and A549 cells were treated with apatinib (20 μM) for 48 h. Western blotting was used to analyze the ADRB2 protein level. D RT-PCR was used to analyze the expression of ADRB2 mRNA. E The expression of ADRB2 was demonstrated by flow cytometry. F Statistical analysis of flow cytometry. G Representative images of immunofluorescent staining for ADRB2. H H522 and H460 cells were exposed to vehicle or anlotinib. The expression of ADRB2 was demonstrated by flow cytometry. I Statistical analysis of flow cytometry. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with control).